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Most people don't want to
spending time in a hospital,

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of course you will say, but perhaps you don't study
medicine like me and you don't have a doctor

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retired as an uncle. He knows everyone
and decided to help me choose the

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specialization. It's not a pill
morphine. It doesn't let everyone through

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suckers from the greatest show on television
doctor of the history of surgery and

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advanced research, although practice
my uncle's hospital is definitely

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experimental.

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Robert is charming, come down again
more.

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It's really too late to sign up for
jurisprudence?

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An opneomologist is a kind of mechanic
of the lungs.

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We use specific instruments, probes,
needles, with which we aspirate fluid from

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lungs. It's interesting because it's possible
see physiology in action.

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As soon as he goes back to sleep he snores
every breath. And when he manages to cure

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patients you know they're going to feel like
they hadn't heard from each other for years. A beautiful one

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breath of fresh air.

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This is an episode to take away the
breath.

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We talk about pneumology, the study of
lungs and respiratory system. The

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it's an engine and we need to create energy.

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Oxygen is fuel and from
combustion generates energy.

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The lungs are the implant of
air intake into the engine e

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exhaust system, because toxic gases
created by the combustion process

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the inside of the cells reach the
lungs that expel them.

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The ailments that affect everyone
other part of the body also involve

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lungs. We are dealing with a vast
spectrum of clinical conditions. Not

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I breathe well.

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Coughing causes pain.

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There, I heard. The panting and the
short stay.

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It's like a cold that doesn't want it
leave.

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The most frequent ailments we can
encounter are emphysema, asthma.

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do you feel it?

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Then there's lung cancer.

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Or diseases such as fibrosicystics.
Breathe and mouth open, please.

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There are infectious diseases that
affect the lungs, pneumonia, i

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tuberculosis. And each one tries to take you away
the breath.

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Every time we breathe, the air from
trachea reaches the bronchi.

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Then the terminal parts of the bronchi, i
bronchioles.

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And finally the ends, the alveoli, where
air exchange takes place.

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The characteristic of the alveoli is
be organs totally covered with

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blood. Through the alveoli l
oxygen enters the blood.

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Once captured by the hemoglobin of
red blood cells, releases oxide

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carbon, waste gas, which comes
eliminated by respiration.

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If we took the alveoli contained in
inside the chest and opened them

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completely, placing them close together
they would cover a very large area.

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How large is this area?

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Well, if we flattened the alveoli and
we would arrange them next to each other,

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they would cover an entire tennis court.

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Inhale through your nose, counting slowly
up to three and then hold.

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One, two...

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I can't hold my breath like
you do it. I'm not good at this

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exercise. You are the one who asked
to see me?

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Hello, doctor. My nephew, you see, has
some breathing problems.

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Really? Well, it's in the right place.
Come, let's take a look right away.

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He thinks I'm having trouble
respiratory. Let him believe so,

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In the meantime, practice.

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Doctors love taking tests and taking pictures.
It doesn't surprise me that the

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pulmonologists are like this.

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Now take a deep breath and...
hold back.

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You exhale, a collapsed lung can be
highlighted by X-rays. There is a

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cavities between the lung sacs which
allows the lungs to stay

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lay down. If damaged, you can too
die from suffocation.

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On the surface of each lung a
there is contact with the inside of the ribs

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pleura. And these two pleurae are found
in opposite positions to each other. A

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consequence of this, a pressure
negative is generated between these

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membranes. which literally sucks them in
sacs by attaching them to the ribs.

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Translated from medicase, the pleurae,
membranes perfectly stretched in directions

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opposite, they form a void called cavity
pleural, which maintains the lungs

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to the ribs.

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As long as he resists the pressure
negative, which is constant and exercised

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entire area, the lungs adhere to the
rib cage. But a wound or the

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fracture of a rib that causes damage
the lung can also cause injury

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a loss of pressure.

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It's called a pneumothorax.

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There is no longer the physical prerequisite
thanks to which the lung adheres to the

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rib cage. This little sphere
what you see is what remains of the lung

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once collapsed due to quantity
of air that has accumulated around

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it.

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Through a tube in the chest yes
sucks in the air restoring the

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pleural.

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Let's inflate the lung.

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generating negative pressure
immediately outside, thanks to the

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lung remains open, as do the
diaphragm and respiratory muscles. In the

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before color TV, doctors
their lungs collapsed on purpose. It was

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attempt to cure tuberculosis,
depriving the bacteria of living space.

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And until antibiotics arrived, the
tuberculosis meant death.

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TB remains one of the main ones
deadly infections worldwide, a

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despite the fact that you cure yourself with
ease and that the therapy has a cost

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only 10 dollars. Soon, a lot of
instruments for lung analysis, among

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which this, this and also this.

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Until 5 minutes before my uncle
told the doctor I was having problems

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respirators, I was breathing very well.

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trying to reach my peace
interior.

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Doctors were also interested in
my interiority, in the true sense of

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word, they were interested in mine
bronchioles.

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If you have symptoms and are unable to
locate a problem with x-rays,

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touches bronchoscopy.

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00:06:05,060 --> 00:06:09,100
We use the flexible bronchoscope
to evaluate the airway

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of the patient and to do so we insert into the
nose this tube equipped with

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and light.

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By doing so we can study the
trachea, the largest airway that

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It is a tool through which
inject pharmacological liquids, be they

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freezing or antihaemorrhagic.

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Let's check the direction of the
bronchoscope through a small lever

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move it back and forth.

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And to move it sideways just do
like this.

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This little rubber thing does everything there
respiratory system up to the bronchi.

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and can take tissue samples.

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There is a small forceps mounted on a
rather long cable contained inside

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inside the probe and at the end c
It is an attachment mouth tweezers

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that opens and closes.

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The tweezers grab a sample of
fabric and removes it.

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By examining it you can diagnose it
tumors or lung infections. But how yes

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he says, exams never end.

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The pulmonary function laboratory
It looks like a gym, except

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instructors wear suits instead
gowns.

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In this laboratory we try to
determine the breathing capacity of the

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patient in different ways.

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It looks a bit like a car
time, but it's called Body Box.

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Doctors test your ability
pulmonary by making you act like a puppy.

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Having inserted the mouthpiece and stapled the nose,
start anti-sea. The is established

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amount of air stored by
chest movement. Now let's get started.

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Antimating the chest and lungs make gods
small movements.

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And thanks to these movements it compresses
the air in the box.

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By measuring the change in pressure
inside the box, we can

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the total volume of air contained in
lungs at that time.

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And now look here, the spirometer.
Bleed the air out. He doesn't study it

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inhalation, but exhalation. How much
exhale and how quickly.

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It's a kind of breathing Olympics.

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Take a deep breath. With the
doctor as coach. And throw it out.

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Do you keep throwing out the air? This
type of measurements are often

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carried out on patients hospitalized at
emergency room and we have a colleague

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who works in the emergency room with a
truly authoritative voice. It makes itself understood

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His patients really do well to that extent
that if you are doing a spirometry ad

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a patient complete with an instrument for
breathing, at least another 5 or 6 yes

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they fill the lungs and empty them a
command, even if I'm in the hospital for

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types of problems.

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So Robert, blow into the mouthpiece
and don't stop until I tell you.

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Doctor, this is really interesting
machinery, a lot has changed

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my times.

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Let me think, if my memory fails me
deceives, we inhale 4 liters...

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No, not 4, 6.

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More or less 6 liters of air every minute.

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Yes, exactly.

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Incredible, incredible the amount of
air moving in and out of the lungs. Ah,

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it's refreshing.

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Isn't that refreshing, Robert?

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In the first second of forced exhalation
up to 80% of the air can escape.

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But this will not be possible if you suffer
of obstructive diseases such as asthma.

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The speed is reduced because the streets
they are blocked. An asthmatic hears

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difficulty getting air into
lungs. This is because it starts to

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too strong an inspirational flow and
this blocks the next inspiration.

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the real problem from the beginning is a
exhalation problem.

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Try to imagine if you had to
find yourself breathing through a straw, for example

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example. You can also learn how to dose
the right amount of air to inhale

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and exhale, but it is not immediate.

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Asthma is a type reaction
immune. It is mainly localized

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bronchioles, the organs responsible for
air transport.

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If the airway is good
conditions, the mucosal wall is

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In an asthmatic patient there is a
tension of the muscle wall around

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these pathways and inflammation is generated
on the walls themselves causing a

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narrowing of the channel through which
the air passes and here there is an increase

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of the secretion. In an asthmatic lung

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These small muscles are contracted,
therefore there are bottlenecks in the streets

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aerial.

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When asthmatics put l
'inhaler, they breathe in drugs that

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they reduce inflammation and dilate the
bronchi.

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A good patient takes his medicine and
everything is fine.

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If he doesn't take his meds, then
problems arise.

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The cause of asthma is still a mystery
absolute. It may depend on the environment or

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it may be genetic.

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Research nowadays is moving forward
on the study of which specific genes

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lead to a higher risk of asthma,
but it is also clear that it is not a question of

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problems related to a single gene,
as in cystic fibrosis, for example.

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Cystic fibrosis is serious business.

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A lot of mucus forms in the lungs
dense, which cannot be freed from

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normal. Hours of therapy are needed every
day, including physiotherapy

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just to breathe.

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He also does this type of therapy at home
or... Yes, I also do it at home, mi

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they help my husband and my mother.

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They are not generic blows on the back,
the hand must generate a particular

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vibration, so the lungs come
help against excess secretions.

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a protein called CFTR that picks up
chlorine from the cells to form the

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salt, sodium chloride.

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Sodium dilutes mucus into phlegm
watery that is easily eliminated

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from the airways.

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In cystic fibrosis patients this
protein is defective.

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Often the problem is a flaw in the
prevents it from working properly.

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And if there is no chlorine there is no salt.

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Result? Mucus does not dilute,
it becomes thick and viscous and clogs them

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areas which become the ideal place for
the bacteria.

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The gene encoding CFTR was discovered
in 1989.

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Scientists are looking for a
drug that acts as a mechanic

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and fix the flaw in the protein.

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Soon, it will never be possible to snore at
death?

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There are cars that really leave you
breathless. To measure capacity

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pulmonary I even fainted.

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Who hasn't slept badly at least once
night? The doctors wanted to see if

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breathing and sleeping difficulties are
connected.

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00:12:38,470 --> 00:12:43,770
I have always found it very interesting
variation of breathing with changes in

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physical conditions. And that has me
led to deal with sleep, because

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sleep changes the way you breathe.
When I get up in the morning, I'm more

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when I went to sleep.

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00:12:54,800 --> 00:12:58,260
I fell asleep during a
interview, a job interview.

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00:12:58,260 --> 00:13:01,760
in the car I have to slap myself not to
fall asleep? I wake up suddenly

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00:13:01,760 --> 00:13:06,980
many times. I mean, I think it's because
I blush a lot when I sleep. The shape

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common respiratory problems that
they can hit us while we sleep yes

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apnea. Apnea means you stop
breathe.

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00:13:15,800 --> 00:13:20,620
There are two types of sleep apnea. The
the first happens if the brain does not command

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to the muscles to breathe.

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00:13:22,010 --> 00:13:25,990
And the second, much more common, is
caused by obstruction of the trachea.

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In obstructive sleep apnea they come
relax the muscles that hold it open

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00:13:30,510 --> 00:13:32,870
the throat and upper airways
they collapse.

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00:13:33,890 --> 00:13:38,950
And the brain receives messages that
they say, so? It doesn't reach the lungs

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00:13:38,950 --> 00:13:40,830
oxygen, air, I can't do it.

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00:13:41,440 --> 00:13:46,180
Wake up! We have a kind of
pacemaker located in the plus area

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00:13:46,180 --> 00:13:50,940
of the brain that reminds us to breathe
and detectors similar to those for typhus

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00:13:50,940 --> 00:13:54,760
which tell us how much oxygen and how much
of carbon monoxide is in ours

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blood.

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00:13:56,580 --> 00:14:00,940
Too much carbon monoxide is bad. THE
The body wants oxygen and wakes up.

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00:14:01,180 --> 00:14:03,060
Sleeping soundly is impossible.

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00:14:09,340 --> 00:14:11,460
Wait here, I'll be right back, okay?

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00:14:13,820 --> 00:14:18,360
Dr. Forge wants to subject you to gods
sleep apnea test. What?

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00:14:18,840 --> 00:14:20,500
Leave it, I'll help you, my dear.

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00:14:21,080 --> 00:14:22,140
Sleep apnea?

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00:14:22,660 --> 00:14:25,640
I have no problem sleeping. See you soon.

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00:14:26,360 --> 00:14:29,740
You're welcome, of course. Good
day, bye.

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00:14:31,240 --> 00:14:35,640
Seriously, I have no problems. I sleep
anywhere anytime. They are the

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of narcolepsy, my boy. It's a
serious problem.

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Come, have a seat. A symptom of apnea
in sleep and sometimes a consequence of

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divorce is snoring. His wife does
complaining because he snores? Me when I sleep

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a terrible noise.

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Even the dog refuses to stay in
room with me.

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But when it means sleep apnea, i
Doctors take this very seriously.

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They sent her to this lab
because it may be sleep apnea.

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You are connected to a computer that
monitor your breathing throughout

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Do you think he sleeps like this at home?

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The most important thing is saturation
of oxygen. If you suffer from apnea in

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sleep, oxygen necessarily drops.

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They monitor dioxide levels
carbon with this tool. From this one

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part there is a light signal.

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And on the other side is a sensor that
detects the signal.

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Proteins that transport oxygen
in the blood they absorb light depending on

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how much oxygen they receive.

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00:15:42,630 --> 00:15:47,950
We can determine how much oxygen
it is saturating the hemoglobin molecules

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from the output voltage. If we breathe
normally 95 -98% of hemoglobin

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it is saturated with oxygen. If the apnea is
serious, oxygen levels can

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descend to the point of suffocation
cell phone.

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But this is nothing more than the effect of
an ongoing disorder.

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To get a complete picture, doctors
monitor muscle contractions,

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00:16:09,870 --> 00:16:11,830
the airways and brain activity.

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00:16:12,070 --> 00:16:17,670
All we need is a few electrodes, two
around the eyes and two under the chin,

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00:16:17,670 --> 00:16:22,130
be able to study the sleep phase
individual REM call, REM sleep.

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00:16:22,730 --> 00:16:27,050
The REM phase of sleep is the most
deep, the one in which the organism

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the forces. If the brain is stimulated to
waking up due to breathing problems, not

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you will sleep deeply and wake up
tired. Ready?

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Yes, I'm ready.

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Have a good sleep. Until tomorrow.

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Doctors study the data to see if
do you suffer from sleep apnea or not.

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00:16:45,450 --> 00:16:50,250
This is a typical layout of a
patient suffering from sleep apnea,

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00:16:50,250 --> 00:16:53,410
the level of oxygen in the blood which
goes up and down, goes up and down.

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And this is the flow path
respiratory.

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00:16:57,970 --> 00:17:01,730
Rib cage and abdomen move
together and here the flow stops instead

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suddenly. Here, this is a
'apnea.

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00:17:04,530 --> 00:17:08,970
And even in the absence of flow there is a
continuous movement of the chest and limb

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'abdomen, indicating that the effort
breathing is done anyway.

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00:17:13,930 --> 00:17:16,910
So we are faced with a
'constructive apnea.

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Essentially this patient remained
for two minutes in apnea without breathing

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at all and the oxygen level in the
blood has dropped to zero limits.

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Soon, the invention that guarantees a
those who suffer from apnea get a good night's sleep

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calm and that I will be lucky enough to
experience personally.

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00:17:40,840 --> 00:17:44,300
Not only lungs, therefore, but also
sleep disorders.

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00:17:45,160 --> 00:17:48,820
As I headed to the lab, I
I was wondering how long you can

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hold your breath.

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00:17:51,080 --> 00:17:55,500
For those suffering from apnea, diagnosis and
therapy can be simultaneous.

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00:17:56,380 --> 00:18:00,320
CPAP means positive pressure
constant to the airways.

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Basically we exercise a
pressure on the airways, allo

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keep channels and walls open
well separated airways.

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00:18:10,780 --> 00:18:16,380
It's a kind of inner tube
pressure with a pneumatic splint for

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clear the airways. The mask
forces the airways to open. I

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00:18:20,960 --> 00:18:24,720
patients don't take a nap,
they fall into a deep sleep that does not

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00:18:24,720 --> 00:18:29,120
they had been trying for a long time. It's called the effect of
return. Who hasn't slept for a long time

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00:18:29,120 --> 00:18:32,100
in REM phase he finally has the possibility
to do it.

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00:18:33,580 --> 00:18:37,060
Thanks to this machine he went from a
hundreds of apneas in an hour

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00:18:37,060 --> 00:18:38,360
essentially none.

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00:18:39,100 --> 00:18:43,900
I highly recommend this type of to you
long-term therapy. The doctors

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00:18:43,900 --> 00:18:48,100
they can provide you with a kit for use
domestic. It has the same kind of

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00:18:48,100 --> 00:18:51,960
operation. The airways yes
they keep open thanks to the pressure

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00:18:51,960 --> 00:18:56,100
exercised and you will all breathe well
the nights of your married life.

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00:18:56,590 --> 00:19:01,350
I sleep very well now. I wake up
full of energy. I'm not tired anymore.

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00:19:01,350 --> 00:19:05,790
suffered for over ten years. The doctors
they worked miracles. Without this

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00:19:05,790 --> 00:19:11,370
car today I certainly wouldn't be here. E
the most important thing of all is that

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00:19:11,370 --> 00:19:12,370
I don't yawn anymore.

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00:19:17,430 --> 00:19:18,470
Well, Robert.

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00:19:18,710 --> 00:19:23,930
Have a good rest. And don't get nervous. You will come
monitored by professional gentlemen.

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00:19:29,160 --> 00:19:33,400
Here we go, doctor. Look at yours
tracked now. The graph of his

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00:19:39,160 --> 00:19:39,740
The

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00:19:39,740 --> 00:19:47,320
too much

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00:19:47,320 --> 00:19:52,020
it's too much. But smoking, even in small
quantity, can cause disorders such as l

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00:19:52,020 --> 00:19:53,860
emphysema and lung cancer.

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00:19:54,330 --> 00:19:59,690
Emphysema results in destruction
of lung tissues and alveoli,

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00:19:59,690 --> 00:20:04,250
via the toxins produced by smoking
cigarette and due to the intervention of

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00:20:04,250 --> 00:20:06,270
immune system that comes let's say...

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00:20:06,560 --> 00:20:11,280
activated by the toxins produced. The
thus stimulated immune system

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00:20:11,280 --> 00:20:15,400
substances so aggressive that
increase damage. The greatest damage is

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00:20:15,400 --> 00:20:20,020
'emphysema is capable of breaking the
protein nuclei and therefore proteins

305
00:20:20,020 --> 00:20:24,720
damaged in this way begin to
eat lung tissue creating gods

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00:20:24,720 --> 00:20:25,980
holes inside the lungs.

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00:20:26,580 --> 00:20:32,400
Healthy lung, smoker's lung. I
Bronchioles are usually branch-like

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00:20:32,400 --> 00:20:34,740
collapsed and the alveoli are not there
more.

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00:20:35,470 --> 00:20:40,430
There are therapies that open the airways,
they partially reduce inflammation, but

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00:20:40,430 --> 00:20:44,470
they do not change the clinical picture. One
once they were destroyed, the

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00:20:44,470 --> 00:20:45,530
they don't reform.

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00:20:45,830 --> 00:20:48,070
You may have lung cancer and
don't know?

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00:20:48,350 --> 00:20:52,290
Patients with lung cancer do not
suffer from shortness of breath, because the

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00:20:52,290 --> 00:20:56,650
cancer itself, apart from the fact of
take up space, it does nothing else in the

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00:20:56,650 --> 00:21:00,230
for this reason that people with the
lung cancer they realize it

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00:21:00,230 --> 00:21:02,450
late and things become much more
difficult.

317
00:21:02,920 --> 00:21:07,020
In the future, dogs will do the work
diagnosis. Their sense of smell smells

318
00:21:07,020 --> 00:21:07,939
of drugs.

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00:21:07,940 --> 00:21:11,880
Maybe he can hear that of the too
cancer before the symptoms explode. E

320
00:21:11,880 --> 00:21:13,500
mice that smell tuberculosis?

321
00:21:13,740 --> 00:21:17,680
Giant rats are already being used for
clear land mines in the Sahara.

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00:21:17,880 --> 00:21:20,860
They are trained to hear the
the smell of diseases.

323
00:21:21,440 --> 00:21:26,460
According to some tests, rodents smell
more than 300 samples with TB in one hour.

324
00:21:26,540 --> 00:21:29,540
We with the microscope only 20 in one
day.

325
00:21:30,280 --> 00:21:35,560
We can't compete. The Bank
World has already invested over 165,000

326
00:21:35,560 --> 00:21:37,620
dollars for anti rat studies
-TB.

327
00:21:39,820 --> 00:21:42,600
If only rats helped stop
smoking.

328
00:21:44,480 --> 00:21:48,820
If there weren't smokers mine
work would be different. I could

329
00:21:48,820 --> 00:21:51,620
my energies on more treatable ailments
of theirs.

330
00:21:51,920 --> 00:21:56,480
Smoking-related disorders are easy
to catch and difficult to cure. Not

331
00:21:56,480 --> 00:21:58,040
it's never too late to stop.

332
00:21:58,510 --> 00:22:01,990
If you do it before the damage is already done
high, maybe you can avoid a

333
00:22:01,990 --> 00:22:03,010
ephesema or cancer.

334
00:22:04,990 --> 00:22:05,990
I breathe well.

335
00:22:06,050 --> 00:22:07,390
It's much better.

336
00:22:08,230 --> 00:22:09,850
I can also sleep better.

337
00:22:10,150 --> 00:22:11,790
I owe everything to these therapies.

338
00:22:12,470 --> 00:22:14,010
I'm alive because of them.

339
00:22:14,490 --> 00:22:19,950
You learn to live with it. You can live,
you can do gymnastics, gym, have

340
00:22:19,950 --> 00:22:20,950
normal life.

341
00:22:21,110 --> 00:22:24,890
Do you want to breathe longer? Have it
care of your lungs.

342
00:22:25,370 --> 00:22:28,250
Take a break, we need some air
fresh, every now and then.

343
00:22:29,490 --> 00:22:34,210
They had measured my ability
pulmonary, expiration times, i

344
00:22:34,210 --> 00:22:38,890
of sleep, and all this breathing,
sleeping, monitoring, had tired me

345
00:22:38,890 --> 00:22:39,890
die.

346
00:22:39,970 --> 00:22:43,850
Yet, according to my uncle, it was still there
a test I had to face.

347
00:22:45,910 --> 00:22:49,450
Very generous of you
offer yourself as volunteers. See you tomorrow morning.

348
00:22:50,090 --> 00:22:51,230
Night, doctor.

349
00:22:54,540 --> 00:22:58,680
Oxygen and carbon dioxide are not
the only gases developed by my uncle.

